Tafseer of Explained in detail · Fussilat · 41:49
Man is not weary of supplication for good [things], but if evil touches him, he is hopeless and despairing.
Important: The Arabic source text is always authoritative. This translation is a study aid and has not been verified by scholars — do not use it as a basis for religious proof or for deriving rulings (ahkam). When in doubt, always consult the Arabic text and a qualified scholar.
And His saying: لا يَسْأَمُ الإِنْسَانُ مِنْ دُعَاءِ الْخَيْرِ ("Man does not tire of supplicating for good") — the Exalted, whose mention is exalted, says: the disbeliever (kāfir) toward Allah does not tire of supplicating for good, that is, of supplicating for good and asking it of his Lord. And "the good" means in this place: wealth and bodily health. He says: he does not tire of asking for that. وَإِنْ مَسَّهُ الشَّرُّ ("but if evil touches him") means: and if harm touches him in himself through illness, or through hardship in his livelihood, or through the withholding of his provision, فَيَئُوسٌ قَنُوطٌ ("then he is despairing and despondent") means: then he is full of despair of relief and deliverance from Allah, despondent of His mercy and of the possibility that this evil which has befallen him might be removed from him.
And in the sense of what we have said concerning this, the exegetes spoke.
* Mention of who said that:
Muḥammad related to us, saying: Aḥmad related to us, saying: Asbāṭ related to us, on the authority of al-Suddī: لا يَسْأَمُ الإِنْسَانُ مِنْ دُعَاءِ الْخَيْرِ ("Man does not tire of supplicating for good"). He says: the disbeliever (kāfir). وَإِنْ مَسَّهُ الشَّرُّ فَيَئُوسٌ قَنُوطٌ ("but if evil touches him, then he is despairing and despondent"): despondent of the good.
Yūnus related to me, saying: Ibn Wahb informed us, saying: Ibn Zayd said concerning His saying: لا يَسْأَمُ الإِنْسَانُ ("Man does not tire"). He said: he does not tire. And he mentioned that this, in the reading of ʿAbd Allāh, reads: "لا يَسْأَمُ الإِنْسَانُ مِنْ دَعَاءٍ بالخَيْرِ" ("Man does not tire of praying for good").